P15: Astrocyte Dysfunction in Epilepsy

P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy

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Tangled roots: digging deeper into astrocyte or interneuron dysfunction in temporal lobe epilepsy.

P8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction

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Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-Depleted Rats

Introduction: Astrocyte dysfunction is the common pathology resulting in failure of astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD). To date, only few experimental models of selective ablation of astrocytes are known. The aim of present study was to evaluate the effect of striatal injections of selective glial toxin L-aminoadipic acid (L-AA) on the loco...

NF-κB-mediated astrocyte dysfunction initiates neurodegeneration

The IKK/NF-κB signal transduction and transcription factor system is a central regulator of inflammation, cell survival and differentiation, and is implicated in multiple human pathologies including multiple sclerosis, glioblastoma and neurodegenerative disorders. The IKK/NF-κB system is prominently activated by proinflammatory cytokines and molecules derived from pathogens or damaged cells and...

Water Homeostasis Dysfunction in Epilepsy

This chapter was originally published in the book Brain Edema, published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non-commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who know you, and providing a copy to yo...